abstract：:A large clinical literature suggests that estradiol (E(2)) plays a critical role in immune function. To further explore the relationship between E(2) and immune function, we examined a variety of immunological parameters in a rhesus monkey model of menopause and hormone replacement therapy. Rhesus monkeys (Age, 13.7+/...

journal_title：Journal of reproductive immunology

authors： Keller ET,Zhang J,Yao Z,Qi Y

更新日期：2001-04-01 00:00:00

abstract：:Pregnancy success is attributed to the joint action of several factors such as regulatory placental molecules and components of the mother's immune system, among others. Asymmetrical glycosilated and functionally univalent IgG antibodies are suggested to influence the immune balance between the mother and foetus, play...

journal_title：Journal of reproductive immunology

authors： Gutiérrez G,Malan Borel I,Margni RA

更新日期：2001-01-01 00:00:00

abstract：:HLA-G is a non-classical MHC class 1 molecule, expressed primarily on human foetal trophoblast cells, which exhibits almost no genetic polymorphism. Because of these unusual features, HLA-G has been suggested to help prevent maternal immune attack of the semi-allogeneic foetus. The aim of these experiments was to inve...

journal_title：Journal of reproductive immunology

authors： Bainbridge DR,Ellis SA,Sargent IL

更新日期：2000-08-01 00:00:00

abstract：:Lymphohematopoietic cytokines play a significant role in many biological mechanisms including a number of reproductive processes such as ovulation, implantation, placentation, cervical dilation and parturition. Recent experiments have suggested that cytokines play a crucial role in the mechanisms of preterm labor and ...

journal_title：Journal of reproductive immunology

authors： Saji F,Samejima Y,Kamiura S,Sawai K,Shimoya K,Kimura T

更新日期：2000-07-01 00:00:00

abstract：:We conducted a large case-control study to assess the risk of preeclampsia with elevated sTNFp55 concentrations (markers of excessive TNF-alpha release) in Peruvian women. A total of 125 women with preeclampsia and 179 normotensive women were included in a study conducted during the period, June 1997 through January 1...

journal_title：Journal of reproductive immunology

authors： Sanchez SE,Zhang C,Williams MA,Ware-Jauregui S,Larrabure G,Bazul V,Farrand A

更新日期：2000-05-01 00:00:00

abstract：:The expression of Fas-ligand (FasL) on trophoblast cells is thought to play a role in immune regulation during human pregnancy. However, there are some discrepancies in the published data concerning the cell types expressing FasL in the placental villi. Therefore, we examined the expression of FasL on cryosections of ...

journal_title：Journal of reproductive immunology

authors： Hammer A,Dohr G

更新日期：2000-03-01 00:00:00

abstract：:Prostaglandins, with cytokines involved as intermediate factors, may have an essential role in premature labour when infection is present. We therefore wanted to study tumour necrosis factor (TNF), in cytokine and prostaglandin production in reproductive tissue. Decidual cell cultures were established and cells were s...

journal_title：Journal of reproductive immunology

authors： Arntzen KJ,Egeberg K,Rahimipoor S,Vatten L,Austgulen R

更新日期：1999-12-01 00:00:00

abstract：:We previously reported that decidual stromal cells (DSC) from early human decidua express antigens associated with hematopoietic cells and develop different immune functions. Here we study the antigenic phenotype of DSC from term decidua and compare it with the phenotype reported for DSC from early decidua. Decidual s...

journal_title：Journal of reproductive immunology

authors： Oliver C,Cowdrey N,Abadía-Molina AC,Olivares EG

更新日期：1999-11-01 00:00:00

abstract：:Alloimmunization therapy using the partner's leukocytes has been reported to be effective in preventing the failure of pregnancy in patients who have suffered RSA of unknown cause. After alloimmunization, several investigators have reported the presence of blocking factors (BF) in women with successful pregnancies in ...

journal_title：Journal of reproductive immunology

authors： Prigoshin N,Tambutti ML,Redal MA,Gorgorza S,Lancuba SM,Nicholson R,Testa R

更新日期：1999-09-01 00:00:00

abstract：:The expression of the nonclassical MHC class Ib molecule HLA-G is nearly exclusively restricted to the feto-maternal interface during pregnancy. There it probably serves the same physiological functions already known for classical MHC class I molecules; these include peptide presentation, natural killer cell (NK) inhi...

journal_title：Journal of reproductive immunology

authors： Münz C,Stevanović S,Rammensee HG

更新日期：1999-07-01 00:00:00

abstract：:Although antisperm autoantibody responses to obstruction of the male reproductive system have been documented, information on the nature of the cognate sperm autoantigens has been limited. In the present study, the patterns of sperm autoantigens recognized by sera from rats after obstruction of the vas deferens or epi...

journal_title：Journal of reproductive immunology

authors： Flickinger CJ,Bush LA,Williams MV,Naaby-Hansen S,Howards SS,Herr JC

更新日期：1999-05-01 00:00:00

abstract：:Lipopolysaccharide (LPS, endotoxin) is a component of the cell wall of gram-negative bacteria and a potent inducer of severe inflammatory reactions. In mice, systemically administered LPS induces fetal resorption and increases fetal mortality. However, effects of intrauterine LPS on fertility, fetal survival and devel...

journal_title：Journal of reproductive immunology

authors： Tuo W,Ott TL,Liu S,Bazer FW

更新日期：1999-01-01 00:00:00

abstract：:The debate about the presence of HIV-1 particles in human gametes and recent experimental results are reported in detail. Using immunocytochemistry, in situ hybridization at electron microscopy level, polymerase chain reaction and in vitro fertilization, it has been demonstrated that human spermatozoa can incorporate ...

journal_title：Journal of reproductive immunology

authors： Baccetti B,Benedetto A,Collodel G,di Caro A,Garbuglia AR,Piomboni P

更新日期：1998-12-01 00:00:00

abstract：:Foreign DNA is spontaneously taken up by mouse epididymal sperm cells and is further internalized into nuclei. The interaction and/or internalization of the exogenous DNA triggers the activation of sperm endogenous nucleases which mediate rearrangements of the internalized DNA. Foreign DNA sequences are found to be ti...

journal_title：Journal of reproductive immunology

authors： Magnano AR,Giordano R,Moscufo N,Baccetti B,Spadafora C

更新日期：1998-12-01 00:00:00

abstract：:Therapeutic interventions and public education are reducing pediatric AIDS cases in developed countries, but the number of HIV-infected women and children is still a major global concern. The finding that human sperm-associated HIV can be transmitted to oocytes following in vitro fertilization provides a novel viewpoi...

journal_title：Journal of reproductive immunology

authors： Douglas GC,Fazely F,Hu JJ

更新日期：1998-12-01 00:00:00

abstract：:The state of pregnancy is an immunological enigma during which the body must prevent rejection of the antigenically foreign fetus while at the same time maintain sufficient maternal host defense mechanisms to combat infection. Although most studies on the immunology of pregnancy focus on immune suppression, several st...

journal_title：Journal of reproductive immunology

authors： Davis D,Kaufmann R,Moticka EJ

更新日期：1998-11-01 00:00:00

abstract：:In order to investigate the regulatory role of only one endometrial cell type on trophoblastic invasion, we explored the effects of culture medium conditioned by in vitro decidualised stromal cells (DCM) and of insulin-like growth factor binding protein-1 (IGFBP-1, the main secretory product of decidual cells) on the ...

journal_title：Journal of reproductive immunology

authors： Bischof P,Meisser A,Campana A

更新日期：1998-08-01 00:00:00

abstract：:The process of ovarian follicular development is a long and arduous one, marked by dramatic proliferation and differentiation of both the somatic and germ cell elements. To a large extent, this explosive agenda is under the control of conventional endocrine principles, involving hormones such as pituitary gonadotropin...

journal_title：Journal of reproductive immunology

authors： Adashi EY

更新日期：1998-08-01 00:00:00

abstract：:Chemokines are a new family of cytokines specialised in attracting leukocytes, acting in physiological conditions and in pathological processes. A wide variety of cell types in response to exogenous irritants or endogenous mediators of the inflammatory reaction produce them. Pivotal parts of reproductive function are ...

journal_title：Journal of reproductive immunology

authors： Simón C,Caballero-Campo P,García-Velasco JA,Pellicer A

更新日期：1998-07-01 00:00:00

abstract：:The aim of this study was to clarify whether amniotic fluid macrophage colony-stimulating factor (M-CSF) is related to placental development and fetal growth. Maternal serum and amniotic fluid M-CSF levels were analyzed in 22 pregnant women (seven intrauterine growth retardation (IUGR) complicated and 15 normal pregna...

journal_title：Journal of reproductive immunology

authors： Murakawa H,Mori S,Iida S,Atsumi Y,Suzuki M

更新日期：1998-02-01 00:00:00

abstract：:There is now evidence that the classical HLA class I molecule HLA-C is expressed on extravillous trophoblasts together with non-classical HLA-G molecules. Since clones of NK-cells are inhibited differently by supertypic epitopes associated with HLA-C and -B alleles we found it of interest to study HLA-C and -Bw polymo...

journal_title：Journal of reproductive immunology

authors： Christiansen OB,Mohapeloa HP,Steffensen R,Jersild C

更新日期：1997-12-15 00:00:00

abstract：:Herpes simplex virus type 2 (HSV-2) is a sexually transmitted pathogen that infects the genital tract. The high prevalence of HSV-2 in humans underscores the need to develop an effective vaccine. Efforts to develop vaccines to protect women against this and other sexually transmitted pathogens would be facilitated by ...

journal_title：Journal of reproductive immunology

authors： Parr MB,Parr EL

更新日期：1997-11-30 00:00:00

abstract：:Several laboratories currently offer panels of serum autoantibody assays to screen women with unexplained infertility and those undergoing in vitro fertilization (IVF). Offering these tests implies that they have predictive value for the outcome of proposed infertility treatments such that the results of the testing w...

journal_title：Journal of reproductive immunology

authors： Hatasaka HH,Branch DW,Kutteh WH,Scott JR

更新日期：1997-09-01 00:00:00

abstract：:Previous studies have shown that the polymeric Ig receptor (pIgR) is produced by rat uterine epithelial cells both in vivo and vitro. The expression of the pIgR is regulated by sex hormones and/or cytokines at mucosal sites, however the mechanism of regulation in the uterus is not clear. In these studies, co-culture o...

journal_title：Journal of reproductive immunology

authors： Richardson JM,Wira CR

更新日期：1997-06-01 00:00:00

abstract：:Epstein-Barr virus (EBV)-transformed B cell lines that produce human antisperm antibodies were established using peripheral blood lymphocytes (PBLs) from infertile women with sperm immobilizing antibodies in their sera. We obtained three stable cell populations (designated B1, B2, D5) of transformed PBLs originating f...

journal_title：Journal of reproductive immunology

authors： Dimitrova-Dikanarova DK,Tsuji Y,Nakata Y,Shibahara H,Mitsuo M,Hashimoto T,Furuyama J,Koyama K

更新日期：1996-12-01 00:00:00

abstract：:The NOD mouse is a model for autoimmune diabetes that develops symptoms similar to Type I diabetes. The incidence of diabetes is greater in females but the degree of insulitis is comparable in both sexes. The purpose of this study was to assess the populations of lymphocytes and macrophages in the pancreas and spleen ...

journal_title：Journal of reproductive immunology

authors： Hawkins TA,Gala RR,Dunbar JC

更新日期：1996-11-01 00:00:00

abstract：:We have investigated serum and intracavitary levels of IL-1 alpha, IL-1 beta and IL-1ra from agonadal women undergoing mock cycles (n = 20) of oocyte donation as a clinical model of controlled hormonal stimulation. Further, we compared the intracavitary IL-1 alpha, IL-1 beta and IL-1ra levels in the microenvironment o...

journal_title：Journal of reproductive immunology

authors： Simón C,Mercader A,Frances A,Gimeno MJ,Polan ML,Remohí J,Pellicer A

更新日期：1996-10-01 00:00:00

abstract：:The feasibility of producing epitope-specific antigens by mutation of the gene is demonstrated, the aim being to eliminate unwanted surface epitopes yet allowing the natural folding of the protein to maintain the desired epitope(s). The model protein is the beta subunit of human chorionic gonadotropin (hCG beta) which...

journal_title：Journal of reproductive immunology

authors： Jackson AM,Klonisch T,Lapthorn AJ,Berger P,Isaacs NW,Delves PJ,Lund T,Roitt IM

更新日期：1996-08-01 00:00:00

abstract：:Placental culture supernatants (PS) obtained from various mouse crossbreedings were added to mouse IgG1 hybridoma cultures producing anti-DNP antibodies. The quantity of monoclonal antibody (mAb) produced, the nature of these antibodies and the proliferation of the hybridoma cells were studied. It was observed that th...

journal_title：Journal of reproductive immunology

authors： Miranda S,Borel IM,Freire SM,Binaghi R,Margni R

更新日期：1996-05-01 00:00:00

abstract：:A method has been developed to establish lines of transformed lymphocytes able to produce in vitro the same anti-sperm antibodies as those naturally occurring in immuno-infertile individuals. We utilized lymphocytes from a male donor whose serum contained anti-sperm antibodies of the IgG class up to the dilution 1:10,...

journal_title：Journal of reproductive immunology

authors： Fusi FM,Besuschio F,De Santis L,Lorenzetti I,Ferrari A

更新日期：1995-07-01 00:00:00

abstract：:Previous studies in our laboratory indicated that immunization of male and female Wistar and Lewis rats with epididymal protein DE, resulted in the development of anti-DE antibodies in over 90% of the animals, with a significant and reversible reduction of fertility. In the present study, ELISA assays performed to ana...

journal_title：Journal of reproductive immunology

authors： Perez Martinez S,Conesa D,Cuasnicú PS

更新日期：1995-05-01 00:00:00

abstract：:Macrophages are a prominent resident cell type in the interstitial tissue of the testis in several mammalian species. This presence in an immunologically-privileged site prompted an investigation of their ability to initiate and regulate lymphocyte proliferation in vitro. Isolated rat peripheral blood lymphocytes (PBL...

journal_title：Journal of reproductive immunology

authors： Kern S,Maddocks S

更新日期：1995-03-01 00:00:00

abstract：:Antisperm autoantibodies were studied in Fischer and Lewis strains of rats after either vasectomy, vasectomy followed one month later by vasovasostomy, or sham operations. The time course of antibody response to sperm protein autoantigens was assayed by Western blot analysis of sera obtained at intervals up to 3 month...

journal_title：Journal of reproductive immunology

authors： Flickinger CJ,Howards SS,Bush LA,Baker LA,Herr JC

更新日期：1995-02-01 00:00:00

abstract：:Fifty-six prepubertal Hereford cross Friesian heifers were assigned to seven treatment groups: (1) primary (day 0) and booster (day 41) using 10 mg human serum albumin (HSA) (control); (2) primary and booster (day 41) immunizations using 3.3 mg prostaglandin F2 alpha PGF-HSA conjugate; (3) primary and booster (day 83)...

journal_title：Journal of reproductive immunology

authors： Crowe MA,Enright WJ,Roche JF

更新日期：1994-12-01 00:00:00

abstract：:The feasibility of using the rhesus monkey as a non-human primate model for testing the efficacy of a contraceptive vaccine based on FA-1 antigen was evaluated. Affinity-purified anti-FA-1 polyclonal antibodies (Fab' fragments) and anti-FA-1 monoclonal antibody were used as probes in these studies. Anti-FA-1 antibodie...

journal_title：Journal of reproductive immunology

authors： Naz RK,Wolf DP

更新日期：1994-10-01 00:00:00

abstract：:Interferon-gamma (IFN-gamma) is a lymphokine, produced by activated T lymphocytes, which plays a key regulatory role in the host immunological responses. In addition, IFN-gamma is expressed by human and porcine trophoblast. As IFN-gamma exerts its biological functions through specific cell surface receptors and a grea...

journal_title：Journal of reproductive immunology

authors： Paulesu L,Romagnoli R,Cintorino M,Ricci MG,Garotta G

更新日期：1994-08-01 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a classical haematopoietic cytokine which has also been implicated in placental growth and development. In this study we have performed a detailed immunohistological localization of the low affinity GM-CSF receptor (GM-CSF-R alpha) in human first trimester i...

journal_title：Journal of reproductive immunology

authors： Jokhi PP,King A,Jubinsky PT,Loke YW

更新日期：1994-03-01 00:00:00

abstract：:Anticardiolipin antibodies (aCL) were eluted from the placentae of four women with elevated serum levels of aCL, demonstrating that these antibodies are bound to affected placentae. Anticardiolipin antibodies bound to affected placentae were only of the IgG isotype and the level of aCL in placental eluates did not ref...

journal_title：Journal of reproductive immunology

authors： Chamley LW,Pattison NS,McKay EJ

更新日期：1993-12-01 00:00:00

abstract：:We have investigated the potential contraceptive effects of immunization against the luteinizing hormone (LH) receptor in male mice at the prepubertal stage. Two N-terminal fragments of the porcine LH receptor encoding amino acids 1-297 and 1-370 were produced in large quantities through the Baculovirus insect cell sy...

journal_title：Journal of reproductive immunology

authors： Remy JJ,Bozon V,Couture L,Goxe B,Salesse R,Garnier J

更新日期：1993-09-01 00:00:00

abstract：:Immunoglobulin classes and subclasses of sperm immobilizing antibodies (SI-Abs) in the sera of sterile women were determined by the absorption of patients' sera with Staphylococcus aureus and immunoadsorbents bound with class or subclass-specific anti-human immunoglobulin antibodies. Among 18 patients' sera tested, 16...

journal_title：Journal of reproductive immunology

authors： Tsuji Y,Tatsumi T,Kameda K,Koyama K,Isojima S

更新日期：1993-08-01 00:00:00